Dictyostelium: genus of protozoa, formerly also considered a fungus; its natural habitat is decaying forest leaves, where it feeds on bacteria; often called cellular slime mold; D. discoideum is the best known species and is widely used in biomedical research. In this study, we established a Francisella infection model using the amoeba Dictyostelium discoideum as a surrogate macrophage and F. noatunensis subsp. This cellular slime mold is a major player in many aspects of medicine and cell research. The cells live as unicellular amoebae in deciduous forest soil, feeding on bacteria that are taken up by phagocytosis and dividing by binary fission. Each meal is a potential infection because some bacteria have evolved mechanisms to resist predation. Each meal is a potential infection because some bacteria have evolved mechanisms to resist predation.
Source: CRISP. Williams1, Katrina Boeckeler1, Ralph Gra¨f2, Annette Mu¨ller-Taubenberger3, Zhiru Li4, Ralph R. Isberg4,5, Deborah Wessels6, David R. Soll6, Hannah Alexander7 and Stephen Alexander7 1Department of Biology and the Wolfson Institute for Biomedical Research, University College London, London, WC1E 6BT, UK
The experimentally versatile Dictyostelium discoideum – Mycobacterium marinum infection model provides a powerful system to study mycobacteria pathogenicity and host response. The soil amoeba D. discoideum can internalize a remarkably wide range of particles, including latex beads, yeast, benign bacteria and different pathogenic bacteria (Cardelli, 2001; Maniak, 2003; Steinert et al., 2003).The cells can be grown easily in the laboratory at 24.5°C. Towards a molecular understanding of human diseases using Dictyostelium discoideum Robin S.B. In this study, we infected single‐cell stages of D. discoideum with different Legionella species. Mycobacterium marinum is the causative agent of fish and amphibian tuberculosis in the wild. The social amoeba Dictyostelium discoideum is increasingly being used as a simple model for the investigation of problems that are relevant to human health. The soil-dwelling social amoeba Dictyostelium discoideum feeds on bacteria. To the Editor: Although Dictyostelium spp. The soil-dwelling social amoeba Dictyostelium discoideum feeds on bacteria. Dictyostelium discoideum is a molecularly amenable host model system for several human pathogens, including Legionella pneumophila, Mycobacterium avium, Mycobacterium marinum, Pseudomonas aeruginosa, and Cryptococcus neoformans.
The similarities between the Dictyostelium and mammalian cells extend to membrane trafficking, endocytic transit and sorting events.
First, we demonstrated that Yersinia pestis is resistant or transiently resistant to various ameba species. are used for studying signal transduction, cytoskeletal functions, endocytosis, and molecular pathogenesis of infectious and other diseases (1), human or animal infections caused by this organism have not been reported.
To survive such a hostile environment, D. discoideum has in turn evolved efficient antimicrobial responses that are intertwined with phagocytosis and autophagy, its nutrient acquisition pathways.
Even if you have never before heard of dictyostelium discoidium you may be quite impressed to go to this huge website that is a well- funded and part of the Human Genome Project and NIH.
Abstract.
To the Editor: Although Dictyostelium spp. Intracellular growth of Legionella in this new host system was compared with their growth in the natural host Acanthamoeba castellanii. Abstract.
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